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Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemBH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersDNA Damage Response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response.


It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with Payday loans online damage response. It has two central gene products (ATM and TP53) which payday loans online connected with the first DNA damage response pathway. Direct p53 effectors, organism-specific biosystemDirect p53 effectorsGene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process.


Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S.


Hippo signaling payday loans online, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans.


Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality. Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN).


Integrated Cancer Pathway, organism-specific biosystemIntegrated Cancer PathwayIntegrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat. Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide.


Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri. Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide.


Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an.


Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers.


Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o. TP53 Network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways.


This protein family presents a high le. TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystemThe tumor suppressor TP53 (p53) exerts its tumor suppressive role in part by regulating transcription of a number of genes involved in cell death, mainly apoptotic cell death.


The majority of apoptot. Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen.


It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue).


The p53 protein is employed as a transcriptional activator of p53-regulated ge. The encoded isoform (1, also known as PUMA-gamma) has the same N-terminus but is otherwise distinct and longer, compared to isoform 2.


Source sequence(s) AA887822, AF354654, BG258126, U82987 Consensus CDS CCDS46129. Source sequence(s) AA887822, AF354655, BG258126, U82987 Consensus CDS CCDS46130. The encoded isoform (3, also known as PUMA-delta) has the same N-terminus but is otherwise distinct and payday loans no credit check shorter, compared to isoform 2. Source sequence(s) AA887822, AF354656, BG258126, U82987 Consensus CDS CCDS46128.


The encoded isoform (4, also known as PUMA-alpha) has a distinct N-terminus and is longer than isoform 2. Isoform 4 also includes the C-terminal BH3 domain and can localize to the mitochondria.


Source sequence(s) AA887822, AF332558, BG258126, U82987 Consensus CDS CCDS12697. Explain This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Order miRNA target clones Order full-length ORF clone Order shRNA clones LifeSpan BioSciences, Inc.


The fall 2017 Fenty Puma by Rihanna show on March 6 during Paris Fashion Week. Puma recently obtained an injunction against Top Shop over similar allegations that the U. Forever 21 has faced scores of lawsuits by retailers and designers, including Puma rival Adidas, Anthropologie, Diane von Furstenberg and Express, accusing the company of copying designs and intellectual property infringement.


Many of the suits against the retailer have ended in confidential settlements. Los Angeles Times staff photographer Jay L.



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We Love Efficiente People  è un'iniziativa volta a premiare un comportametno da pare dei nostri utenti che ci permette di operare in modo più efficiente.

  • 5% di sconto per il gruppo che prenota un viaggio  o un'iniziativa con 20 giorni di anticipo.
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logo vela al femminilelogo vela al femminile

Vela al Femminile è un'iniziativa di Andar per Mare per favorire l'avvicinamento delle donne al mondo della vela.

Su ogni iniziativa di Andar per Mare le donne potranno usufruire del 10% di sconto.

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LET ME GROW  è un'iniziativa di Andar per Mare per favorire l'avvicinamento dei giovani al mondo della vela.

Su ogni iniziativa di Andar per Mare i ragazzi al di sotto dei 24 anni potranno usufruire del 10% di sconto.

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Ricarica

Cosa vuol dire skipper alla pari.

Lo skipper alla pari è il comandante a tutti gli effetti dell'imbarcazione. E' responsabile della vostra sicurezza, pianifica le rotte, conduce l'imbarcazione, contatta i porti, e fa tutto ciò che è necesario per la riuscita del viaggio ma non riceve denaro. Il suo compenso è viaggiare senza dover spendere soldi per carburante, cambusa di bordo e soprattutto i ristoranti. Quindi se andate a mangiare da qualche parte invitatelo e soprattutto non fategli pagare il conto! :) .

Inoltre lo skipper alla pari organizza e provvede all'acquisto delle provviste (utilizzando i soldi destinati alla cambusa), a volte riesce a pescare ma assolutamente non cucina, ne lava i piatti.

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